Silver Dragon has become a bane to the werewolf community in recent years. Designer heroin, one that actually affects were creatures where normal drugs are simply a passing fancy, has infiltrated the St. Louis werewolves. One of these, a young woman named Anna Maddox, wants her brother back somehow from the brink he’s standing at. To do this, she reaches out to the ancient order, the Children of Asclepius. Duncan Powell hears her plea and pledges to help her rescue her brother from the streets of St Louis.  
 
He goes to Detective Sebastian Pearce, a member of Unit Zero, the law enforcement agency that deals with supernatural creatures that pose a threat to the peace in the world. Sebastian implores him to leave things to Unit Zero, but Duncan is stubborn and goes down to the Red District to find the young Were. Sebastian and his partner follow and then begin the mission that will either save Kacey Maddox or doom all of them.